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as of 7/2/2022

Country - Partner Institution - Programs: Netherlands - Utrecht University - 'Utrecht Univ.'
UC Course SubjectBiological Sciences
Number & Suffix: 107
Transcript Title: GENES & GENOMES 
UC QTR Units - Division: 6.0 - Upper Division 
Course Description: This course offers a study of how genetic factors that influence human traits are identified, with a focus on human diseases. Students review background knowledge necessary to understand and apply different identification methods, molecular laboratory techniques, and approaches to finding causal variants for human heritable diseases, as well as utilize databases containing human genetic information. The course is divided into two distinct subjects. The first subject examines the general organization of the genome of higher eukaryotes. Topics in this subject include comparative genomics and genome annotation such as gene structure, gene duplication, molecular phylogeny, genome analysis, species comparisons, and software and databases; functional genomics such as functional annotation of genes, gene expression, and proteomics; and how knowledge is obtained, and how information can be extracted from existing sources. The second subject explores the identification of mutations that influence human diseases. Topics in this subject include linkage analysis; laboratory aspects of DNA research such as the techniques, their interpretation, and the causes of artefacts; positional cloning and prioritizing genes within a defined region including mutation analysis, and the role of new technology; and molecular pathology, including how mutations change phenotypes, and how to prove it. The course consists of lectures, readings, exercises, and group work. The course requires that students have knowledge of the structure and organization of DNA; the processes of meiosis and mitosis, including recombination; transcription, and translation; gene expression; and laboratory techniques such as PCR, restriction enzymes, and DNA-hybridization as a prerequisite. 
Language of Instruction: English
Partner University Department: Biomedical Sciences 
Partner University Course Number: BMW20605